史蒂文斯-约翰逊综合征和有毒表皮解剖的眼部并发症:综合性审查
Kiana Hassanpour1, Hassan Asadigandomani2, Sahel Soltani Shahgoli3
1Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seminars in ophthalmology
|August 25, 2025
概括
史蒂文斯 - 约翰逊综合征 (SJS) 和毒性表皮解体 (TEN) 可能导致严重的眼睛问题. 早期和持续的眼科护理对于管理这些并发症和保护受影响患者的视力至关重要.
科学领域:
- 眼科 眼科
- 皮肤病学
- 药理学
背景情况:
- 史蒂文斯-约翰逊综合征 (SJS) 和毒性表皮解体 (TEN) 是严重的粘膜皮肤反应,通常是药物诱导的.
- 眼部感染是致病的重要原因,可能导致失明.
研究的目的:
- 审查SJS/TEN中的临床表现,病理生理学和眼部并发症的治疗.
- 综合目前关于急性和慢性眼病表现和治疗的证据.
主要方法:
- 对现有文献进行叙述性回顾.
- 关于SJS/TEN眼部并发症和治疗的综合文献搜索.
主要成果:
- 多达75%的SJS/TEN患者患有急性眼部损伤 (结膜炎,角膜侵蚀).
- 早期治疗 (滑,皮质类固醇,AMT) 可以减轻损伤;慢性问题包括眼睛干燥.
- 长期治疗包括脑膜透镜,手术 (LCST,MMG) 和角膜假体;ProKera®有助于愈合.
结论:
- 眼部SJS/TEN需要早期,持续,多学科的护理来保护视力.
- 在急性阶段及时的眼科干预和慢性治疗是必不可少的.
- 需要进一步研究标准化方案和新疗法以改善结果.
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