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初级肝神经内分泌癌的快速进展:一个显示严重瘤行为的病例报告

Rina Kobayashi¹, Tomohide Hori¹, Makoto Yamawaki²

¹Department of Surgery, Yokkaichi Hazu Medical Center, Yokkaichi, Mie, Japan.

The American journal of case reports

|August 25, 2025

概括

主要肝神经内分泌癌 (PHNEC) 是罕见的,难以诊断的. 这一病例突显了快速进展和非典型的成像特征,强调了临床意识和及时诊断的必要性.

科学领域:

肝胆细胞瘤
神经内分泌瘤
癌症成像

背景情况:

原发性肝神经内分泌瘤 (PHNEN) 异常罕见,而原发性肝神经内分泌癌 (PHNEC) 是一种亚型.
虽然通常生长缓慢,但神经内分泌与非神经内分泌的混合瘤会表现出侵略性行为和不良预后.
由于它们的稀有性和通常微妙的初始表现,PHNENs带来了诊断挑战.

研究的目的:

报告一个罕见的初级肝神经内分泌癌 (PHNEC) 病例,癌症进展迅速.
详细介绍这个激进的PHNEC的全面成像发现和诊断时间表.
阐明与非典型PHNEC呈现相关的潜在诊断陷和临床影响.

主要方法:

一位73岁的男性患者偶然发现了肝脏瘤.
使用简单的计算机断层扫描 (CT),磁共振成像 (MRI),多普勒超声波,动态CT和正电子发射断层扫描 (PET) /CT进行瘤评估.
组织病理学和免疫组织化学评估,包括Ki-67标记指数,证实了诊断.

主要成果:

偶然检测出一个42毫米的单一肝脏瘤,
随着肝脏和门静脉血栓的逐渐扩大,以及转移性淋巴结的发展.
尽管开始化疗,但在82天内疾病迅速进展至终期.

结论:

这种情况突显了PHNEC癌症的快速进展的可能性,与典型的缓慢生长模式相反.
详细的成像发现对于识别异常呈现和避免诊断延迟至关重要.
提高临床警和对诊断陷的认识对于管理罕见和侵袭性PHNEC至关重要.

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