相关实验视频
Updated: Sep 10, 2025
05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
844
慢性病负担估计的差异:来自不同的来源,定义和方程
Yao Ma1, Xiang Wang2, Weihong Zhao1
1Division of Nephrology, Department of Geriatrics, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, China.
PloS one
|August 25, 2025
概括
根据数据来源和计算方法,估计慢性病负担有所不同. 根据年龄调整的值和EKFC方程为研究和临床环境中的CKD患病率提供了更好的准确性.
科学领域:
- 肝脏病学
- 流行病学
- 公共卫生
背景情况:
- 全球疾病负担 (GBD) 研究提供了慢性病 (CKD) 的流行病学数据.
- 在GBD估计与其他来源之间存在差异,需要进一步调查.
- 需要仔细考虑膜过率 (GFR) 的标准和计算工具.
研究的目的:
- 通过各种数据来源,定义和方程来评估CKD的负担.
- 为了比较GBD研究和国家健康和营养检查调查 (NHANES) 的CKD患病率估计.
- 评估不同GFR方程和年龄调整的值对慢性病患病率的影响.
主要方法:
- 使用GBD 2021和NHANES数据对美国成年人 (1999-2018) 中的CKD流行情况进行分析.
- 按性别计算平均患病率和估计年均百分比变化 (EAPC).
- 各种定义和方程的比较,包括全球文献综述.
主要成果:
- 来自GBD和NHANES的年平均CKD患病率估计是相似的,但长期趋势不同,特别是在性别特定的群体中.
- 删除种族系数改变了黑人和白人CKD患病率的估计.
- EKFC 方程导致了最高的CKD 患病率;年龄调整的门将低 eGFR 患病率降低了 ~50%.
结论:
- 在各种来源和方法中,估计的CKD患病率存在显著差异.
- 根据年龄调整的门和灵活的EKFC方程显示了改善CKD评估的潜力.
- 这些发现对治疗慢性病的流行病学研究和临床实践有影响.
相关概念视频
01:28Chronic Kidney Disease III: Interprofessional Care
78
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
78
01:25Chronic Kidney Disease I: Introduction
67
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
67
01:17Factors Affecting Renal Clearance: Renal Impairment
157
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
157
01:22Acute Kidney Injury I: Introduction
72
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
72
01:24Chronic Kidney Disease II: Clinical Manifestations
87
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
87
01:11Renal Failure: Dose Adjustments
153
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
153