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研究领域生物医学和临床科学心血管医学和血液学心脏病 (包括心血管疾病)
大型缺血性心脏病的内血管治疗与医疗管理: ANGEL-ASPECT试验的1年结果

大型缺血性心脏病的内血管治疗与医疗管理: ANGEL-ASPECT试验的1年结果

Xiaochuan Huo ¹, Dapeng Sun ^2,3, Thanh N Nguyen ⁴, Gaoting Ma ⁵, Yuesong Pan ^2,3, Xin Tong ¹, Guangxiong Yuan ⁶, Hongxing Han ⁷, Wenhuo Chen ⁸, Ming Wei ⁹, Jiangang Zhang ¹⁰, Zhiming Zhou ¹¹, Xiaoxi Yao ¹², Weigen Song ¹³, Xueli Cai ¹⁴, Guangxian Nan ¹⁵, Di Li ¹⁶, Alvin Yi-Chou Wang ¹⁷, Wentong Ling ¹⁸, Chuwei Cai ¹⁹, Changming Wen ²⁰, En Wang ²¹, Liyong Zhang ²², Changchun Jiang ²³, Geng Liao ²⁴, Xiaohui Chen ²⁵, Tianxiao Li ²⁶, Shudong Liu ²⁷, Jinglun Li ²⁸, Yaxuan Sun ²⁹, Na Xu ³⁰, Zong'en Gao ³¹, Dongsheng Ju ³², Cunfeng Song ³³, Feng Zhou ³⁴, Qing Shi ³⁵, Jun Luo ³⁶, Yan Liu ³⁷, Zaiyu Guo ³⁸, Hongbo Zheng ³⁹, Linzhi Dai ⁴⁰, Junfeng Zhao ⁴¹, Xiaokun Geng ⁴², Yufeng Tang ⁴³, Congguo Yin ⁴⁴, Hua Yang ⁴⁵, Xuelei Zhang ¹, Shuo Li ¹, Mohamad Abdalkader ⁴, Feng Gao ^2,3, Ning Ma ^2,3, Dapeng Mo ^2,3, Zeguang Ren , Liping Liu ^46,3, Yongjun Wang ^46,3, Zhongrong Miao ^2,3,

Xiaochuan Huo ¹, Dapeng Sun ^2,3, Thanh N Nguyen ⁴

¹Cerebrovascular Disease Department, Neurological Disease Center, Beijing Anzhen Hospital (X.H., X.T., X.Z., S. Li), Capital Medical University, China.
²Department of Neurology, Interventional Neuroradiology (D.S., Y.P., F.G., N.M., D.M., Z.M.), Beijing Tiantan Hospital, Capital Medical University, China.
³China National Clinical Research Center for Neurological Diseases, Beijing (D.S., Y.P., F.G., N.M., D.M., L.L., Y.W., Z.M.).
⁴Department of Neurology, Radiology, Boston Medical Center, MA (T.N.N., M.A.).
⁵Department of Neurology, Beijing Xuanwu Hospital (G.M.), Capital Medical University, China.
⁶Department of Emergency, Xiangtan Central Hospital, Hunan, China (G.Y.).
⁷Department of Neurology, Linyi People's Hospital, Shandong, China (H.H.).
⁸Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China (W.C.).
⁹Department of Neurosurgery, Tianjin Huanhu Hospital, China (M.W.).
¹⁰Department of Neurology, Anyang People's Hospital, Henan, China (J. Zhang).
¹¹Department of Neurology, Yijishan Hospital of Wannan Medical College, Anhui, China (Z.Z.).
¹²Department of Neurology, The First People's Hospital of Chenzhou, Hunan, China (X.Y.).
¹³Department of Neurology, Yancheng Third People's Hospital, Jiangsu, China (W.S.).
¹⁴Department of Neurology, Lishui Municipal Central Hospital, Zhejiang, China (X. Cai).
¹⁵Department of Neurology, China-Japan Union Hospital of Jilin University, Jilin (G.N.).
¹⁶Department of Neurointervention, Dalian Municipal Central Hospital of Dalian University of Technology, Liaoning, China (D.L.).
¹⁷Department of Neurosurgery, The First Hospital of Hebei Medical University, China (A.Y.-C.W.).
¹⁸Department of Neurology, Zhongshan City People's Hospital, Guangdong, China (W.L.).
¹⁹Department of Neurology, Shantou Central Hospital, Guangdong, China (C.C.).
²⁰Department of Neurology, Nanyang Central Hospital, Henan, China (C.W.).
²¹Department of Neurology, Taizhou Hospital of Zhejiang Province, Zhejiang, China (E.W.).
²²Department of Neurosurgery, Liaocheng People's Hospital, Shandong, China (L.Z.).
²³Department of Neurology, Baotou Central Hospital, Inner Mongolia, China (C.J.).
²⁴Department of Neurology, Maoming People's Hospital, Guangdong, China (G.L.).
²⁵Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangdong, China (X. Chen).
²⁶Department of Cerebrovascular Disease, Henan Provincial People's Hospital Zhengzhou University, China (T.L.).
²⁷Department of Neurology, Yongchuan Hospital of Chongqing Medical University, China (S. Liu).
²⁸Department of Neurology, The Affiliated Hospital of South West Medical University, Sichuan, China (J. Li).
²⁹Department of Neurology, Shanxi Provincial People's Hospital, China (Y.S.).
³⁰Department of Neurology, The Second Affiliated Hospital to Xiamen Medical College, Fujian, China (N.X.).
³¹Department of Neurology, Shengli Oilfield Central Hospital, Shandong, China (Z. Gao).
³²Department of Neurology, Songyuan Jilin Oil Field Hospital, China (D.J.).
³³Department of Interventional Neuroradiology, Liaocheng the Third People's Hospital, Shandong, China (C.S.).
³⁴Department of Neurology, Taiyuan Central Hospital, China (F.Z.).
³⁵Department of Neurology, Affiliated Jiangmen Traditional Chinese Medicine Hospital of Ji'nan University, Guangdong, China (Q.S.).
³⁶Department of Neurology, Sichuan Mianyang 404 Hospital, China (J.L.).
³⁷Department of Neurology, Jingjiang People's Hospital, The Seventh Affiliated Hospital of Yangzhou University, Jiangsu, China (Y.L.).
³⁸Department of Neurosurgery, Tianjin TEDA Hospital, China (Z.G.).
³⁹Department of Neurology, West China Hospital, Sichuan University, (H. Zheng.).
⁴⁰Department of Neurosurgery, First Affiliated Hospital School of Medicine Shihezi University, Xinjiang, China (L.D.).
⁴¹Department of Neurology, Siping Central People's Hospital, Jilin, China (J. Zhang).
⁴²Department of Neurology, Beijing Luhe Hospital (X.G.), Capital Medical University, China.
⁴³Department of Neurology, Mianyang Central Hospital, Guangzhou, China (Y.T.).
⁴⁴Department of Neurology, Hangzhou First People's Hospital, Zhejiang, China (C.Y.).
⁴⁵Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, China (H.Y.).
⁴⁶Department of Neurology (L.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China.

⁰Cerebrovascular Disease Department, Neurological Disease Center, Beijing Anzhen Hospital (X.H., X.T., X.Z., S. Li), Capital Medical University, China.

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2025年八月25日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

与医疗治疗相比,内血管治疗 (EVT) 改善了急性缺血性中风患者的一年结果. 在亚洲人群中,EVT在功能独立和减少残疾方面表现出持久的好处.

科学领域

神经学
干预心脏病学
脑卒中医学

背景情况

血管内治疗 (EVT) 显示大缺血核心中风的90天效果.
大型缺血核心的亚洲患者的一年EVT与医疗管理 (MM) 的结果仍未得到充分研究.

研究的目的

在 ANGEL- ASPECT 试验中,与 MM 相比,评估 EVT 的 1 年功能结果.
评估长期有效性和安全性,在一个亚洲大队列前部循环大血管封闭.

主要方法

第三阶段,随机的,开放的,盲目的终点评估试验 (ANGEL-ASPECT).
患有大缺血核心的患者 (ASPECTS 3-5或70-100毫升心脏病发作) 随机分为1:1 EVT或MM.
主要结局:1年后修改的兰金表 (mRS) 的变化;次要结局:功能独立,行走,死亡率.

主要成果

EVT 显示了一年 mRS 分布的可能性更大 (概率比为 1.25,P=0. 04).
在 EVT 组中,功能独立性 (mRS 0 - 2) 和独立行走能力 (mRS 0 - 3) 显著提高.
一年死亡率在各组之间是相似的;EVT的功能独立益处从90天缩小到1年.

结论

在患有大缺血性中风和近道动脉堵塞的患者中,EVT显著降低了残疾,并带来了持续1年的好处.
这些发现支持EVT作为在24小时内出现的精选中风患者的优秀治疗选择.

关键词:

护理人员心脏病发作缺血性中风预后情况血栓切除术

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