老年人营养风险指数预测了活检证明的糖尿病病患者的功能衰竭
Takayuki Uemura1, Masatoshi Nishimoto1, Masahiro Eriguchi1
1Department of Nephrology, Nara Medical University, Nara, Japan.
Diabetes research and clinical practice
|August 25, 2025
概括
较低的老年营养风险指数 (GNRI) 预测糖尿病病患者的功能衰竭,即使考虑到肌肉质量独立的标志物. 营养状况对于DN的预后至关重要.
科学领域:
- 肝脏病学
- 糖尿病学
- 营养科学
背景情况:
- 老年营养风险指数 (GNRI) 是已知的预后指标.
- 营养不良可能会不准确地膨胀基于肌素的球过率 (eGFR),特别是在糖尿病病 (DN) 中.
- 本研究研究了GNRI在DN的预后价值,考虑肌肉质量独立的功能标志物.
研究的目的:
- 评估GNRI与脏预后之间的关联,在活检证明的糖尿病脏病患者中.
- 为了确定GNRI是否预测功能衰竭与替代疗法 (KFRT) 独立于肌肉质量独立的功能标志物.
主要方法:
- 这是一项观察性研究,涉及405名生物检测证明了DN的患者.
- 脏活检中的老年营养风险指数 (GNRI) 是主要暴露.
- 用多变量考克斯回归分析评估GNRI和KFRT在6. 7年的中位随访期间之间的关联.
主要成果:
- 经过对临床和组织病理因素进行调整后,较低的GNRI与较高的KFRT发生率显著相关 (HR: 3. 13 [1. 74- 5. 61]).
- 即使对肌肉质量独立的功能标志物进行进一步调整,如血清β2- 微球蛋白或肌肉质量调整的EGFR,这种关联仍然显著.
- 在405名患者中,99名患者在随访期间出现了KFRT.
结论:
- 低GNRI是糖尿病脏病患者功能衰竭的独立预测指标.
- 根据GNRI,营养状况对DN患者的预后起着至关重要的作用.
- 需要进一步的研究来探索营养干预措施在减缓DN功能下降方面的潜在益处.
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