听力障碍发病后痴呆的风险:国家队列研究
Arad Kodesh1, Riki Taitelbaum-Swead2, Hannah Kuper3
1Department of Community Mental Health, University of Haifa, Haifa, Israel; Mental Health Department, Meuhedet Health Services, Tel Aviv, Israel.
Journal of the American Medical Directors Association
|August 25, 2025
概括
新发病的听力障碍显著增加了痴呆的风险. 早期监测和干预,如助听器,可能有助于减轻这种风险.
科学领域:
- 神经科学
- 流行病学
- 老年学
背景情况:
- 之前关于听力障碍和痴呆风险的研究存在矛盾.
- 之前的研究中可能存在的偏差仍然未经测试,因此需要进一步调查.
研究的目的:
- 调查所有原因听力障碍和发展痴呆症的风险之间的关联.
- 解决现有文献中关于听力损失和痴呆症的不一致性和潜在偏见.
主要方法:
- 一项国家队列研究涉及102067名年龄在51-71岁之间的参与者,来自以色列卫生维护组织.
- 对发生性痴呆症进行长达17. 2年的随访,听力障碍作为时间变化的共变量.
- 用对20个混因素进行调整的反向概率加权的考克斯回归模型来评估痴呆风险.
主要成果:
- 听力障碍的发病与所有原因痴呆的风险几乎翻了一番 (调整后HR,1. 91).
- 听力障碍患者的痴呆发病率为8. 9%,而听力障碍患者的发病率为4. 11%.
- 补充分析表明,助听器使用可能会降低痴呆风险,而有些人则建议适度反向因果关系.
结论:
- 听力障碍的出现与痴呆的风险增加有关.
- 监测听力障碍对于实施预防性痴呆症策略至关重要.
- 使用助听器和助听器可以在预防痴呆症方面发挥作用.
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