运动可以调节耐力运动员的血虹膜素水平:对帕金森病的影响
Piergiorgio Grillo1, Deborah Di Martino2, Alessandra Calculli2
1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; IRCCS Mondino Foundation, Pavia, Italy; The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, Department of Neurology, NYU Langone Health, NY, United States.
身体炼 (PE) 对帕金森病 (PD) 患者有好处,可能是通过素. 强烈的PE与血里素的降低有关,特别是在男性中,这表明里素可能会在PD中调解运动的益处.
科学领域:
- 神经科学
- 运动生理学
- 内分泌学
背景情况:
- 已知体育炼可以改善帕金森病的临床结果.
- 在PD中,底层机制,特别是神经保护性蛋白质 (如虹膜蛋白) 的作用尚不清楚.
- 在PD患者进行强度炼时,对素作用的体内数据有限.
研究的目的:
- 在一个独特的PD患者群体和健康对照群体 (HC) 中调查血里素水平.
- 研究血虹膜素,疾病状况,运动水平和PD临床结果之间的关系.
- 通过强烈的PE检查血虹膜的性别依赖调节.
主要方法:
- 九十三名参与者被分为四组:PD-静止 (PD-SD),PD-耐力运动员 (PD-EA),HC-静止 (HC-SD) 和HC-耐力运动员 (HC-EA).
- 对参与者进行了临床和人口特征评估,并测量了血里素水平.
- 进行统计分析以比较组和评估相关性.
主要成果:
- 与PD-EA相比,PD-EA患者的疾病持续时间较长,但运动功能更好 (MDS-UPDRS-part III) 和认知评分 (MMSE).
- 耐力运动员 (PD和HC) 的血虹膜素水平明显低于久坐的人,不论疾病状态如何.
- 在PD-SD患者中,较低的血虹膜与男性性别相关,与疾病严重程度 (MDS-UPDRS-part III,HY,LEDD) 有正相关.
结论:
- 慢性,强烈的PE改善了PD患者的神经症状.
- 激烈的PE以性别依赖的方式调节血里素水平,男性较低.
- 虹膜可能在中介PE在PD中的有益临床效果中发挥作用,因此需要进一步研究.
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