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口服大麻醇增加了马的热门值,没有生理上的不良影响

Anna T Carroll¹, Rachel A Reed², Londa J Berghaus²

¹Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA.

American journal of veterinary research

|August 25, 2025

概括

大麻二醇 (CBD) 油通过增加热值,在马中提供间歇性疼痛缓解. 这项研究发现,口服CBD在马类受试者中安全且耐受良好.

科学领域:

兽医药物学
马的疼痛治疗方法
大麻素研究

背景情况:

大麻 (CBD) 是一种非精神活性化合物,来自大麻,具有潜在的治疗性质.
了解CBD对马的疼痛和生理参数的影响对于其临床应用至关重要.
关于CBD治疗马匹疼痛的有效性和安全性的研究有限.

研究的目的:

评估口服大麻醇 (CBD) 对马的热和机械疼痛值的影响.
评估CBD对关键生理变量的影响,包括心率,呼吸率和直肠温度.
在马类模型中确定口服CBD的安全性和耐受性.

主要方法:

一个随机的,掩盖的交叉研究,涉及6匹马接受口服3. 48 mg/ kgCBD油或安慰剂治疗3天.
在基线和给药后4小时和12小时测量了热和机械感知值.
与值测量同时记录了生理参数 (心率,呼吸率,直肠温度).

主要成果:

在第二天 (12小时) 和第三天 (4小时) 服用大麻素 (CBD) 导致热值显著升高,表明间歇性反感受.
没有观察到CBD对机械感知值有显著影响.
在研究中的马中,CBD治疗没有改变心率,呼吸率或直肠温度.

结论:

大麻 (CBD) 通过口服显示其作为马的间歇性止痛药的潜力,特别是通过调节热痛感知.
这些发现表明,在测试剂量中,CBD是安全的,并且能很好地耐受.
需要进一步的研究,以探索CBD的长期疗效和最佳剂量,以治疗马的各种疼痛症状.

关键词:

疼痛缓解剂大麻二醇大麻素一匹马没有疼痛.

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