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在致命辐射之前的二甲基前列腺素E2 改善长期免疫抑制

Tong Wu1, P Artur Plett1, Carol H Sampson1

  • 1Departments of Medicine.

Radiation research
|August 25, 2025
PubMed
概括

通过保护淋巴原体,16-二甲基前列腺素E2 (dmPGE2) 防止了辐射暴露后的长期免疫抑制. 这表明dmPGE2对于辐射事故幸存者和放射治疗患者来说是一种潜在的辐射保护剂.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...