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视觉功能和OCT参数在乙醇诱导的视觉神经病变的评估:一个纵向研究

Gaurav Sachdeva¹, Rebika Dhiman¹, Dharam Raj¹

¹Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.

The British journal of ophthalmology

|August 25, 2025

概括

与乙醇相关的有毒视神经病变 (EON) 会导致渐进的结构损伤,即使视力有所改善. 乳头瘤束 (PMB) 和状细胞内部层 (GC- IPL) 的厚度预测了EON患者的视力恢复.

科学领域:

眼科眼科
神经科学
毒理学

背景情况:

乙醇是结核病治疗的关键抗生素.
与乙醇相关的有毒视神经病变 (EON) 可能会损害视力.
了解EON的结构和功能影响对于患者管理至关重要.

研究的目的:

评估与乙醇相关的有毒视神经病变 (EON) 患者的结构和视觉功能变化.
为了确定视觉恢复的预测因素.

主要方法:

在95名患有EON的成年人和100名对照人群中进行前性研究.
评估视觉敏度,色彩视觉,对比度和视野.
使用光谱域光学连贯断层 (SD-OCT) 来测量视网膜神经纤维层 (RNFL),乳头瘤束 (PMB) 和黄斑结节细胞内状层 (mGC-IPL) 的厚度.

主要成果:

在停止服用药物后,52%的EON眼睛显示出视力改善.
在基线时,RNFL和PMB的厚度相似,但在6个月后显著减小.
在基线时,GC- IPL厚度和GCL体积显著降低,随着时间的推移进一步恶化.
GC-IPL厚度,GCL体积和PMB厚度与最终的视力 acuity 有负相关性.

结论:

在EON的逐步结构损伤表明潜在的不可逆转性,尽管一些视觉恢复.
PMB厚度,GC-IPL厚度和GCL体积是EON视觉结果的重要预测因素.

关键词:

视神经危险因素视力

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