抗糖尿病药物标与精神疾病之间的关联
Rui Yuan1, Guorui Zhao1, Zhe Lu2
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Schizophrenia (Heidelberg, Germany)
|August 25, 2025
概括
改变糖尿病药物的用途可能会带来新的精神治疗方法. 高GANC基因表达降低双极性疾病的风险,而ABCC8基因表达增加精神分裂症的风险,指导未来的药物开发.
科学领域:
- 神经科学
- 药理学
- 遗传学
背景情况:
- 精神疾病是一个重大的全球健康挑战,治疗方案有限.
- 糖尿病和精神疾病之间的并发症表明共享生物途径.
- 改变现有的抗糖尿病药物的用途,
研究的目的:
- 研究将抗糖尿病药物用于精神疾病治疗的可能性.
- 确定特定的抗糖尿病药物点,并评估它们与精神疾病风险的关联.
- 探索这些关联的基因和分子机制.
主要方法:
- 鉴定了60种抗糖尿病药物中的32种向基因.
- 使用脑组织eQTL/pQTL数据和精神疾病GWAS进行了门德尔随机分析.
- 进行了局部化,复制,单细胞和功能分析.
主要成果:
- 增加的GANC表达与双极性疾病风险降低有关;米格利托尔对抗可能会增加风险.
- 增加的ABCC8表达与更高的精神分裂症风险有关;硫氨酸/ 格林化物抑制可能会降低风险.
- GANC和ABCC8通过通道,胰岛素分泌和葡萄糖代谢途径影响精神风险.
结论:
- GANC和ABCC8是精神疾病的潜在治疗点.
- 建议在双相情感障碍患者中谨慎使用米格利托.
- 硫氨酸和氨酸在精神分裂症治疗中具有潜在的用途.
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