两种草药配方的胃肠功能和肠道微生物群调节的比较评估
Saeid Khakisahneh1, Jing-Hua Wang1, Xue-Ying Zhang2,3
1Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814 Siksa-dong, Ilsandong-gu, Goyang-si, 10326, Republic of Korea.
Scientific reports
|August 25, 2025
概括
通过调节肠道荷尔蒙,减少炎症和调节肠道微生物群,Shihosogan-tang (SST) 比Yijung-tang (YJT) 更有效地治疗洛佩拉胺诱导的消化不良. 这两种配方都改变了肠道微生物组成.
科学领域:
- 胃肠病学
- 药理学
- 草药研究
背景情况:
- 消化不良是一种常见的,难以治疗的疾病,
- 草药具有治疗胃肠道疾病的潜力,因此需要进一步的证据.
研究的目的:
- 为了比较Shihosogan-tang (SST) 和Yijung-tang (YJT) 在治疗小鼠的洛佩拉胺诱导的消化不良的疗效.
- 研究SST和YJT的潜在作用机制.
主要方法:
- 使用洛佩拉米德 (LOP) 诱导了一种大鼠饮食不良模型.
- 鼠用SST,YJT或莫萨普里德 (阳性对照) 进行治疗.
- 分析了对肠道参数,血清激素,基因表达和肠道微生物群的影响.
主要成果:
- 与YJT不同的是,SST显著改善了肠道的长度,通行率和格林水平.
- YJT 增强了排便和骨形态,
- 两种SST和YJT都调节了与运动,炎症和水吸收相关的十二指肠基因表达.
- SST和YJT改变了肠道微生物群的β多样性,而莫萨皮德则没有.
结论:
- 在缓解洛佩拉胺诱导的消化不良方面,SST表现出优于YJT的效果.
- 潜在的机制包括肠道激素的调节,炎症和肠道微生物群.
- 需要对食不良的草药配方机制进行进一步的研究.
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