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在炎症性肠病患者中,与一般和中心肥胖相关的死亡风险:长期前性队列研究
Qian Zhang1, Yutao Wang1, Si Liu1
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.
中部肥胖和体重不足增加了炎症性肠病 (IBD) 患者的死亡风险,而不是一般肥胖. 控制内脏脂肪和确保充足的营养是改善IBD患者结果的关键.
科学领域:
- 胃肠病学
- 临床流行病学
- 肥胖研究
背景情况:
- 炎症性肠病 (IBD) 是一种具有显著发病率和死亡率的慢性疾病.
- 肥胖对IBD患者的长期结果的影响需要进一步阐明.
- 了解人体风险因素对于改善患者预后至关重要.
研究的目的:
- 在一大群IBD患者中研究一般肥胖 (按BMI定义) 和中心肥胖 (通过多个指数定义) 与全因死亡率之间的关联.
- 区分与IBD不同肥胖表型相关的死亡风险.
- 为改善IBD的长期存活确定可修改的风险因素.
主要方法:
- 对5107名IBD患者进行了前性队列研究.
- 使用身体质量指数 (BMI) 来评估一般肥胖症.
- 使用腰围 (WC),腰比 (WHR),体重调整的腰指数 (WWI),形指数 (CI) 和A体形指数 (ABSI) 来评估中心肥胖.
- 所有原因的死亡率是主要结果,使用Cox比例风险模型分析了14. 6年的中位数随访.
主要成果:
- 与正常BMI患者相比,体重不足患者的死亡风险增加了2. 22倍.
- 在一般肥胖 (按BMI定义的超重或肥胖) 和全因死亡率之间没有发现显著的关联.
- 较高的WC,WHR,WWI,CI和ABSI四分位数与增加的死亡风险有显著的关联,表明了剂量反应关系.
结论:
- 中部肥胖和体重不足,但不是一般肥胖,是IBD患者全因死亡的重要预测因素.
- 这些发现强调了内脏脂肪减少和适当的营养状况在提高IBD患者的长期存活率方面的关键作用.
- 针对人体构成和营养支持的有针对性的干预措施可以改善IBD患者的预后.
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