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评估劳动诱导对自闭症谱系障碍风险的影响
Omri Zamstein1, Tamar Wainstock2, Eyal Sheiner3
1The Obstetrics and Gynecology Division, Soroka University Medical Center, Ben-Gurion University of the Negev, P.O.B 151, Beer-Sheva, Israel. omrizam@post.bgu.ac.il.
劳动诱导与自闭症谱系障碍 (ASD) 的更高发病率有关. 然而,考虑到其他因素,劳动诱导并不是自闭症发展的独立风险因素.
科学领域:
- 围产期环境暴露
- 神经发育障碍
背景情况:
- 鉴定自闭症谱系障碍 (ASD) 的环境因素仍然具有挑战性,因为研究结果不一致.
- 引产是一种常见的产科干预, 促使研究其在自闭症发展中的潜在作用.
研究的目的:
- 调查劳动诱导与儿童自闭症谱系障碍 (ASD) 风险之间的联系.
- 探索潜在的协同因素影响自闭症发作与分娩诱导.
主要方法:
- 针对单子婴儿进行了基于人口的队列研究.
- 卡普兰-梅尔生存曲线和考克斯比例危险模型用于分析与分娩诱导相关的自闭症发生情况,并调整混变量.
主要成果:
- 在115,081例分娩中,分娩诱导发生在11.4%,并且与更频繁的妊娠并发症有关.
- 与自发分娩 (0.6%) 相比,诱导分娩组的儿童患ASD的发生率更高 (1.0%).
- 经过对母体和围产因素进行调整后,产妇诱导并不是自闭症的重要独立风险因素 (调整后HR=1.21,p=0.063).
结论:
- 在初步分析中,引发分娩与ASD发病率较高存在关联.
- 调整产妇和产周因素, 否定了劳动诱导作为自闭症的独立风险因素.
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