激素替代疗法和肌肉损失:使用DXA的巴尔的摩长度研究的重复测量分析
Elena Ghotbi1, John McGready2, Roham Hadidchi1
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Outpatient Center, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD, 21287, USA.
Skeletal radiology
|August 25, 2025
概括
绝经后妇女使用激素替代疗法 (HRT) 与60岁后脂肪增加的减少有关. 这种对人体构成的保护作用随着年龄的增长而减弱,对瘦肉质量没有影响.
科学领域:
- 老年学和内分泌学
- 妇女的健康和身体组成
背景情况:
- 更年期伴随着身体组成的显著变化,包括脂肪质量的增加.
- 激素替代疗法 (HRT) 是治疗更年期症状的常见干预措施.
- 了解HRT对身体构成的长期影响对于妇女健康至关重要.
研究的目的:
- 研究激素替代疗法 (HRT) 与身体组成的纵向变化之间的关联.
- 检查年龄如何改变绝经后妇女的HRT与身体组成之间的关系.
主要方法:
- 使用了来自巴尔的摩长度老化研究 (BLSA) 的数据,包括经过更年期的女性,并进行了多次DXA测量.
- 根据许多基线特征,员工倾向比较HRT使用者和非使用者.
- 应用线性混合效应模型,将年龄作为时间变化的共变量,以评估HRT对脂肪和瘦肉质量的影响.
主要成果:
- 群体使用者 (n=91) 和匹配的非使用者 (n=220) 具有相似的基线特征.
- 在瘦身量方面没有观察到显著的年龄与HRT相互作用.
- 使用HRT与60岁前的脂肪增加有关,但60岁后的脂肪增加显著减少,这种保护作用随着年龄的增长而减弱.
结论:
- 在60岁以后的绝经后妇女中,使用激素替代疗法 (HRT) 与脂肪积累减少有关.
- 随着年龄的增长,HRT对脂肪质量的有益作用会减弱.
- 在该队列中,没有观察到HRT使用与瘦身量之间的差异关联.
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