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使用液化床涂层纳米纤维素悬浮剂增强乙胺
1Drug Product Development, Research and Development, Abbvie Inc, 1 N. Waukegan Road, North Chicago, Illinois, 60064, USA.
使用纳米纤维素进行液化床涂层显著提高了乙氨基的可取性和强度. 这种方法减少了填充剂的需求,提供了更高效的制药制造工艺.
科学领域:
- 制药技术
- 材料科学
- 化学工程
背景情况:
- 乙氨基 (APAP) 的可用性通常受到其机械性质的限制.
- 助剂填充剂通常用于改善APAP片剂配方,但增加生产成本.
- 纳米纤维素已成为增强药物药片性能的潜在材料.
研究的目的:
- 调查纳米纤维素对乙氨基 (APAP) 的流化床涂层,以提高可分片性.
- 评估纳米纤维素涂层度和加工条件的影响.
- 用于纳米纤维素应用的流化床涂层与双螺丝挤出进行比较.
主要方法:
- 使用流化床涂层对APAP涂上水性纳米纤维素悬浮剂.
- 涂层度和加工参数有系统地变化.
- 通过测量拉伸强度和配方要求来评估平板性.
- 液化床涂层的结果与之前的双螺丝挤出数据进行了比较.
主要成果:
- 在APAP上成功涂上高达2.0%的纳米纤维素涂层.
- 使用2.0%重量的纳米纤维素涂层将APAP片的拉伸强度提高了近200%.
- 对于可接受的药片制造,涂层APAP的填充剂含量需要减少60%.
- 流体化床涂层和双螺丝挤压都产生了类似的平板性能增强.
结论:
- 液化床涂层是应用纳米纤维素以提高APAP的可性的一种有效方法.
- 纳米纤维素度是决定可片性改善的主要因素,而不是涂层方法.
- 这种方法显著减少了填充剂辅助剂的需求,优化了药片的配方.
- 流化床涂层在控制液体添加和实现更高的涂层度方面具有优势.
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