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Updated: May 4, 2026

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation
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通过激活TLR9 / IRG1 / itaconate代谢途径,CpG-oligodeoxynucleotides可以改善氨酸诱导的巨细胞损伤

Yibai Qu1,2, Zehui Jiang3, Zhixia Chen4

  • 1Department of Anesthesiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China.

Molecular medicine (Cambridge, Mass.)
|August 26, 2025
PubMed
概括

通过激活巨细胞,CpG ODN可以防止乙氨基引起的肝损伤. 这一过程涉及免疫反应基因1 (IRG1) 和伊塔康酸,可减少氧化应激和亡.

关键词:
乙氨基一个 IRG伊塔科纳酸肝脏损伤巨细胞亡线粒体功能障碍

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Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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