血动脉指数及其与2型糖尿病风险相关的5年变化:10年队列研究
Liuding Wen1, Yuying Wu1, Xueru Fu1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Cardiovascular diabetology
|August 26, 2025
概括
随着时间的推移,较高的血动脉指数 (AIP) 与患2型糖尿病 (T2DM) 的风险增加有关. 这项研究强调AIP是中国农村人口T2DM的重要预测因素.
科学领域:
- 心血管疾病流行病学
- 代谢综合征研究
- 糖尿病病变的发生
背景情况:
- 全球2型糖尿病 (T2DM) 负担不断增加,特别是在资源有限的环境中.
- 传统的血糖监测是必不可少的,但血无氧指数 (AIP) 是一个新兴的补充预测指标.
- 对AIP和T2DM风险的长期关联缺乏了解.
研究的目的:
- 调查基线血血指数 (AIP) 和其5年变化与2型糖尿病 (T2DM) 风险之间的关联.
- 根据AIP参数对中国农村群体进行T2DM风险分析.
主要方法:
- 在中国农村地区对14968名没有糖尿病的患者进行前性队列研究.
- AIP 计算为 log ((三糖/HDL-C) 并分为四分位数.
- 用于评估10年T2DM风险的多变量考克斯回归,受限立方线,子组和灵敏度分析.
主要成果:
- 在10.4年内,2,165名参与者患有T2DM.
- 基线AIP的四分位数增加与较高的T2DM风险显著相关 (aHR范围为1. 17至1. 96).
- 在AIP的5年增加增加了T2DM风险18%,而降低了20%;观察到线性关系.
结论:
- 基线AIP水平和5年AIP变化都与T2DM风险相关.
- 基线AIP较高和AIP增长趋势预测T2DM发展的可能性更高.
- 在这种人群中,AIP是T2DM风险评估的有价值生物标志物.
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