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用TNF-α抑制剂重新激活B型肝炎:评估抗病毒预防的有效性 - - 系统性审查和元分析的方案

Alhalabi Marouf1, Sawan Sedra2,3

  • 1Department of Gastroenterology, Damascus Hospital, Damascus, Syria. dr.marouf@gmail.com.

Systematic reviews
|August 26, 2025
PubMed
概括

TNF-α 抑制剂可能导致B型肝炎的重新激活 (HBVr). 在接受TNF-α治疗的患者,特别是慢性或隐性HBV感染患者中,抗病毒预防对于预防HBVr至关重要.

关键词:
阿达利穆马布抗TNF-α卡尔托利祖马布皮戈尔埃坦尼西特戈利穆马布乙型肝炎乙型肝炎的重新激活Infliximab瘤死亡因子α抑制剂

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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