在患者控制的静脉静脉止痛术中比较不同剂量的水利摩:随机对照试验
Xinlong Li1, Minjun Liu1, Gang Chen1
1Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 Qingchun East Road, Shangcheng District, Hangzhou, Zhejiang Province, China.
BMC anesthesiology
|August 26, 2025
概括
通过患者控制的静脉注射止痛药 (PCIA) 给予不同剂量的水晶,在腹腔镜手术后显示出类似的疼痛缓解效果. 0. 25毫克剂量提供了最佳的疼痛控制平衡和较少的副作用.
科学领域:
- 麻醉学
- 药理学
- 手术恢复
背景情况:
- 有效的术后疼痛管理对于腹腔镜手术后患者的康复至关重要.
- 患者控制的静脉止痛 (PCIA) 使用阿片类药物,如水晶,是治疗手术疼痛的常见方法.
- 为了平衡止痛和不良事件,在PCIA中优化水利剂量至关重要.
研究的目的:
- 通过PCIA对不同剂量 (0. 20 mg, 0. 25 mg, 0. 30 mg) 的止痛疗效和安全性进行比较.
- 评估不同剂量的水晶对腹腔镜手术患者的疼痛评分,康复指数和不良事件的影响.
主要方法:
- 这是一项随机对照试验,涉及111名接受腹腔镜手术的患者.
- 患者在没有背景输液的情况下接受了PCIA,根据玻尿酸剂量分为三组:0. 20 mg,0. 25 mg或0. 30 mg.
- 主要终点是手术后24小时的视觉模拟尺度 (VAS) 疼痛评分;次要结局包括其他时间点的疼痛,消耗,恢复和不良事件.
主要成果:
- 两组在任何时间点都没有观察到VAS疼痛得分的显著差异.
- 与其他组相比,0. 20 mg组需要显著更多的玻尿酸剂.
- 服用0. 25毫克组的不良反应发生率较低,包括恶心,吐和头,没有报告呼吸抑制.
结论:
- 在腹腔镜外科手术后,0. 20 mg,0. 25 mg和0. 30 mg玻尿酸催化剂具有同等的止痛效果.
- 在有效的疼痛缓解和良好的安全性之间,0. 25毫克的水晶剂量似乎提供了最佳的平衡,其特点是较少的不良事件.
- 在0. 20毫克剂量时观察到更高的注射频率,这表明这种较低剂量的患者控制的止痛效果可能较低.
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