曾经患有妊娠前,对大鼠产后中风的严重程度产生负面影响
Ari Kropf1, Jennifer L Anderson1, Milena Esposito1,2
1Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington, VT, USA.
概括
以往的孕前 (PE) 通过增加缺血敏感性和氧化应激加重产后中风损伤. 这些发现凸显了PE对母亲心血管健康的持久负面影响.
科学领域:
- 神经科学
- 心血管科学
- 生殖生物学
背景情况:
- 孕前 (PE) 是一种孕期疾病,具有长期心血管风险,包括产后中风.
- 以前的PE可能会在产后期加剧缺血损伤.
- 氧化应激和附带输液等潜在机制需要调查.
研究的目的:
- 确定先发性 (PE) 是否会在产后期 (PP) 恶化缺血性中风损伤.
- 研究氧化应激和附带 perfusion 在这种恶化中的作用.
主要方法:
- 有正常妊娠 (NormP-PP) 或实验性PE (ePE-PP) 的雌性大鼠经历了中脑动脉暂时封闭 (tMCAO).
- 测量了脑血流 (CBF),心脏病发作,以及循环氧化应激标志物.
- 通过压力肌肉学来评估皮质附带血管功能.
主要成果:
- 与NormP-PP小鼠相比,PE-PP实验小鼠的内脏病发作和水明显增加.
- 尽管具有相似的CBF,但ePE-PP动物对缺血损伤的敏感度更高.
- 在ePE-PP大鼠中观察到氧化应激标志物 (8-异素,3- 尼托素) 的升高和平附带肌性度的增加.
结论:
- 之前的实验PE加剧了产后血性中风的结果.
- 这种恶化与缺血敏感性增加,附带功能受损和氧化应激增加有关.
- 在产后仍存在PE的病理影响,对中风的结果产生负面影响.
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