相关实验视频

Updated: Sep 10, 2025

Author Spotlight: Exploring Glial Influence in Experience-Dependent Synaptic Pruning During Critical Periods

Author Spotlight: Exploring Glial Influence in Experience-Dependent Synaptic Pruning During Critical Periods

Published on: March 1, 2024

在感觉区的受体经验依赖的重新配置调节神经元的可塑性

Nathan Harris^1,2, Priya Dutta¹, Nikhila Krishnan^1,3

¹Department of Biology, Brandeis University, Waltham, MA 02454.

bioRxiv : the preprint server for biology

|August 26, 2025

概括

温度变化通过协调基因表达和蛋白质贩运而改变神经元功能,使得C. elegans AFD热感神经元具有适应性可塑性.

科学领域:

神经科学
细胞生物学
感官生物学

背景情况:

神经元根据经验通过在不同时间尺度上运行的机制动态调整特性.
主要的感觉神经元利用翻译后的修改进行快速的适应和转录的变化进行长期的调整.
对于功能适应的感觉神经元中的转录和后转录途径的协调仍然不太清楚.

研究的目的:

调查温度体验如何调节C. elegans AFD热感神经元的热感受转录和贩运.
阐明神经元对温度变化的反应可塑性的协调机制.
了解含PY动机的适配蛋白 (PYT-1) 在调节热受体功能和贩运中的作用.

主要方法:

在温度上升后对AFD神经元中PYT-1和GCY-18的转录上调的分析.
研究GCY-23热受体的亚细胞局部化和贩运动态.
评估PYT-1依赖性内细胞分裂及其在GCY-23贩运中的作用.
确定对GCY-18/GCY-23比率进行PYT-1调节的必要性.

主要成果:

温度上升导致AFD神经元中的GCY-18和PYT-1的转录上调.
在AFD感官末端的GCY-18积累与GCY-23的局部变化和增加的逆向流通有关.
需要PYT-1依赖的内细胞分裂来进行GCY-23的转移,调节GCY-18与GCY-23的比率.
这种调节对于将AFD响应值转移到更温暖的温度至关重要.

结论:

AFD热感神经元的体验依赖性可塑性由协调的转录和后转录机制调节.
传感受体转录和传输的时间协调微调神经元对环境刺激的反应.
这项研究揭示了在单个神经元类型中整合短期 (贩运) 和长期 (转录) 适应的新机制.

关键词:

美国航空航天局类植物热感应器甲基酸塑性人口贩运

更多相关视频

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

相关概念视频

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...

Introduction to Special Senses

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...