假冒的Xanax®药片:澳大利亚维多利亚州的临床和查数据的比较研究
Rebekka Syrjanen1,2, Shaun L Greene2,3,4, Sarah E Hodgson2,3
1Department of Forensic Medicine, Monash University, Southbank, Victoria, Australia.
Addiction (Abingdon, England)
|August 26, 2025
概括
假冒的阿尔普拉佐拉姆产品往往含有危险的新精神活性物质 (NPS),而不仅仅是阿尔普拉佐拉姆. 社区使用这些非法药物显示出对其实际成分的认识不足.
科学领域:
- 法医毒理学
- 药物监督管理
- 非法药物分析
背景情况:
- 越来越多的假冒类药物被发现含有未经监管的新精神活性物质 (NPS).
- 了解社区对这些假冒产品的接触对于公共健康至关重要.
- 阿尔普拉佐拉姆 (一种类药物) 是假冒药品生产的常见目标.
研究的目的:
- 将被查获的假冒阿尔普拉佐拉姆产品中检测到的药物与已报告的阿尔普拉佐拉姆使用的临床病例进行比较.
- 描述疑似伪造的阿尔普拉佐拉姆产品在社区中的使用和成分.
- 随着时间的推移,确定假冒阿尔普拉佐拉姆中NPS检测的趋势.
主要方法:
- 澳大利亚维多利亚的警方查获毒品和临床网络 (EDNAV) 的观察性研究.
- 查获的药片和血液样本分析药物含量,包括阿尔普拉佐拉姆和NPS.
- 2020年3月至2022年8月期间警方查获和临床病例之间的检测模式的比较.
主要成果:
- 警方查获的产品中有60.2%含有类NPS,其中常见的产品标有"Xanax®"",Kalma®"或"Mylan®".
- 11. 2% 的临床病例报告了非处方阿尔普拉佐拉姆的使用,平均年龄为 26 岁.
- 观察到NPS检测的显著转变,从2020年的etizolam转移到2021年的clonazolam和2022年的clobromazolam.
结论:
- 被扣押的假冒阿尔普拉佐拉姆产品经常含有未公开的NPS,这表明存在重大公共健康风险.
- 消费者对这些假冒药片的成分的认识很有限.
- 调查结果强调需要加强药物监测和公共卫生干预.
相关概念视频
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
241
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
241
01:29Anxiolytic Drugs: Benzodiazepines and Buspirone
1.2K
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
1.2K
01:26Anxiolytic Drugs: Overview
483
Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
483
01:19Pharmacovigilance
989
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
989
01:54The Placebo Effect
6.3K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.3K
01:28Depressants
175
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
175