在皮肤上安装的补丁中,可以通过表面外的道进行基于应变的流体流动控制
Rana Altay1, Hudson Gasvoda1, Max Mailloux-Beauchemin2
1Department of Bioengineering, Santa Clara University, CA 95053, USA. raltay@scu.edu.
Lab on a chip
|August 26, 2025
概括
研究人员开发了新的表面微通道 (OSMiC), 这些OSMiC可调节,无电源流体控制,用于皮肤液体的应用.
科学领域:
- 材料科学
- 生物医学工程
- 流体力学
背景情况:
- 传统的生物机械依靠压缩来产生压力,因为材料在张力下自然膨胀.
- 微流体设备通常需要外部电源来启动流体.
研究的目的:
- 介绍和描述产生拉伸应变压力的表面微通道 (OSMiC).
- 研究微通道几何,机械应变和流体流动之间的关系.
- 展示一种新的,无功率的流体控制元件,用于基于应变的应用.
主要方法:
- 使用OSMiCs制造的单体多甲基 (PDMS) 贴片.
- 在单轴拉伸压力下的OSMiC行为特征.
- 调查纹,曲和回落现象.
- 测量流体流量产生压力.
- 数字模拟验证实验观察结果.
主要成果:
- OSMiC表现出负体积应变,在拉力应变下产生压力.
- 通过改变形状 (变形) 的特性实现调节,不对称的压力产生.
- 最大向前 (向后) 流量压力为10 (-14) kPa,测量在20%的单轴应变时.
- 通过集成具有不同Q值的OSMiC来证明离散应变激活流量控制.
- 成功展示了无功耗的OSMiC皮肤贴片用于液体注射.
结论:
- OSMiC提供了一个基于拉力应变的生物力学流体执行的新机制.
- 开发的技术使可穿戴和可植入设备的可调节,无电源流体控制成为可能.
- OSMiC为应变敏捷的微流体应用提供了多功能平台,包括药物输送.
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