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Updated: May 8, 2026

In Vivo Three-Dimensional Two-Photon Microscopy to Study Conducted Vascular Responses by Local ATP Ejection Using a Glass Micro-Pipette
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人性化抗P2X4 scFv 降低ATP诱导的P2X4电流并调节人类DRG神经元的兴奋性

Nesia Zurek1,2, Mark W Shilling1, Jenna B Demeter1

  • 1Department of Anesthesiology & Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM.

Molecular pain
|August 26, 2025
PubMed
概括

一种针对人体感官神经元P2X4受体 (P2X4R) 的新疗法对慢性疼痛有很大希望. 这种P2X4R抗体碎片降低了神经元刺激能力,

关键词:
P2X4受体人类DRG离子通道治疗疼痛的方法没有.感官神经元

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...