免疫检查点抑制剂治疗癌症的免疫相关不良事件
Katie Liao1, Emily Martin1, Amy Body2,3
1Department of Rheumatology, Monash Health, Melbourne, Victoria, Australia.
Internal medicine journal
|August 26, 2025
概括
癌症免疫疗法提高了生存率,但在许多患者中引起了与免疫相关的不良反应. 这篇综述详细介绍了RAE,重点介绍了风湿问题及其管理.
科学领域:
- 癌症学
- 关节病学
- 免疫学
背景情况:
- 癌症免疫疗法在过去十年里彻底改变了瘤治疗.
- 改善癌症存活率导致免疫相关不良事件 (irAEs) 的增加,影响患者的比例高达71. 5%.
- 导致严重的发病率和死亡率,往往需要停止治疗.
研究的目的:
- 总结有关irAEs的发病率,病理生理学,诊断和治疗的当前文献.
- 专注于IRAs的风湿性表现.
- 解决缺乏证据的问题,并为改善临床指南提供基础.
主要方法:
- 对免疫疗法和IRE的现有文献进行系统审查.
- 对发生率,机制,诊断标准和治疗策略的数据进行分析.
- 基于病例报告和专家的共识,针对性地审查了类风湿性IRA.
主要成果:
- 造成严重的并发症.
- 类风湿性IRAE是这些事件的一个显著子集,需要特别注意.
- 目前的管理指南主要基于有限的证据,强调需要进一步研究.
结论:
- 在现代癌症治疗中,
- 对患者的治疗结果来说,最好地识别和管理irrAEs,特别是类风湿性表现.
- 需要进行进一步的研究,以建立基于证据的强有力的irAE管理指南.
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