血压和痴呆症全因死亡率:全国的队列研究
Jung Eun Yoo1,2, Kyungdo Han3, Jin-Hyung Jung4
1Department of Family Medicine, Healthcare System Gangnam Center Seoul National University Hospital, 152 Teheran-ro, Gangnam-gu, Seoul 06236, Republic of Korea.
Age and ageing
|August 26, 2025
概括
痴呆症患者的高血压与死亡率有U形联系. 低血压和高血压都会增加痴呆的死亡风险.
科学领域:
- 老年学
- 神经学
- 心脏病学
背景情况:
- 高血压管理至关重要,但对其对痴呆症患者的影响的数据有限.
- 这项研究探讨了被诊断患有痴呆症的人的血压和整体死亡率之间的关系.
研究的目的:
- 在一大群痴呆症患者中,研究缩血压 (SBP) 和腹缩血压 (DBP) 与全因死亡率之间的关联.
- 确定与该人群死亡风险增加相关的特定血压范围.
主要方法:
- 在2008年至2016年间对146832名新诊断患有痴呆症的人进行了分析.
- 根据SBP和DBP水平对参与者进行分类;使用多变量Cox比例危险回归来评估全因死亡率.
- 通过抗痴呆药物处方和ICD-10代码确认了痴呆症的诊断.
主要成果:
- 在SBP和死亡率之间发现了反向的J形关联,最低风险约为138 mmHg.
- 与SBP120-129 mmHg相比,SBP<100 mmHg和SBP≥160 mmHg的死亡风险显著增加.
- 死亡风险在较高的血压下线性增加,血压≥90mmHg与70-79mmHg相比显示较高的风险.
结论:
- 患有痴呆症的个人表现出SBP与全因死亡率之间的反向J形关联.
- 从≥90mmHg开始的高血压与痴呆症患者的死亡风险显著增加有关.
- 这些发现在所有痴呆症亚型和患者亚组中一致,包括老年人和服用抗高血压药物的患者.
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