阻塞性睡眠呼吸暂停治疗对艾滋病毒常见症状的影响
David L Berry1, Jeremy E Orr1, Christopher N Schmickl1
1University of California San Diego, Division of Pulmonary Critical Care and Sleep Medicine, La Jolla, CA.
Journal of acquired immune deficiency syndromes (1999)
|August 26, 2025
概括
在感染艾滋病毒 (PLWH) 的人群中,使用正气压 (PAP) 治疗阻塞性睡眠呼吸暂停 (OSA) 可以改善疲劳和心血管健康标志物. 这凸显了PLWH中OSA评估和治疗的重要性.
科学领域:
- 睡眠医学
- 心脏病学
- 传染病 (艾滋病毒/艾滋病)
背景情况:
- 艾滋病毒感染者往往会感到疲劳,心血管疾病的风险也会增加.
- 阻塞性睡眠呼吸暂停 (OSA) 在PLWH中很常见,可能导致这些健康问题.
- 在PLWH中OSA治疗的影响仍未得到充分研究.
研究的目的:
- 研究正气道压力 (PAP) 治疗对艾滋病毒感染者 (PLWH) 疲劳和心血管健康的影响.
- 评估OSA治疗后睡眠质量,白天嗜睡和认知功能的变化.
主要方法:
- 120名PLWH接受了多睡眠测试,并填写了验证的问卷.
- 患有OSA的参与者接受了为期12周的阳性气道压力治疗.
- 在治疗后重新评估了心血管标志物 (RHI,心率,血压) 和患者报告的结果.
主要成果:
- 在患有OSA的70名参与者中,有41人使用PAP治疗.
- PAP治疗显著改善了疲劳,反应性高血压指数 (RHI) 和心率 (p<0. 05).
- 在白天的嗜睡,睡眠质量和认知功能的感知方面也观察到改善,尽管变化很小.
结论:
- 阳性气道压力 (PAP) 疗法有效改善了艾滋病毒 (PLWH) 患者的疲劳和心血管健康标志物.
- 这些结果与非PLWH群体的结果一致,支持PAP治疗的有效性.
- 应考虑对OSA进行评估和治疗,以控制常见症状并改善健康结果.
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