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在鼻腔状细胞癌中隐藏的节点参与

Samer T Elsamna¹, Aman M Patel², Ibraheem Shaikh²

¹Department of Otolaryngology-Head & Neck Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida.

American journal of rhinology & allergy

|August 26, 2025

概括

隐藏的节点参与 (ONI) 在10. 9%的鼻皮状细胞癌 (SNSCC) 患者中存在,并对存活率产生负面影响. 淋巴血管侵袭 (LVI) 是ONI的主要预测因素,这表明选择性部剖析可能有利于这些患者.

科学领域:

癌症学
头部和部手术
癌症研究

背景情况:

鼻状细胞癌 (SNSCC) 是一种侵袭性癌症.
选择性部剖析 (END) 不是SNSCC的标准,但可能会发生隐藏的节点参与 (ONI).
了解ONI发生率和影响对于治疗决策至关重要.

研究的目的:

评估阴鼻状细胞癌 (SNSCC) 中隐藏节点参与 (ONI) 的发生率.
确定与ONI相关的因素.
评估ONI对患者存活时间的影响.

主要方法:

针对SNSCC患者的国家癌症数据库 (2004-2016) 的分析.
包括患者的人口统计,临床病理和治疗数据.
应用单变量/多变量逻辑回归和卡普兰-梅尔分析来预测和评估ONI.

主要成果:

在522名SNSCC患者中,发现了10. 9%的隐藏节点干扰 (ONI).
ONI是一个显著的负面预后因素,将3年生存率从65%降低到35%.
淋巴血管侵袭 (LVI) 是ONI的唯一预测因素 (OR: 6. 75),ONI的发病率在LVI患者中达到31. 4%.

结论:

隐藏的节点参与 (ONI) 影响了超过10%的鼻皮状细胞癌 (SNSCC) 病例,并使预后恶化.
淋巴血管侵袭 (LVI) 是ONI的一个关键预测因素.
患有LVI的患者可以从选择性部剖析 (END) 中获益,以改善结果.

关键词:

结节转移隐秘节点其他状细胞癌生存时间

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