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Updated: Sep 10, 2025

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
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PERK-p38 MAPK轴驱动福克斯内皮角膜缩症中的内质网膜压力诱导的亡

Takako Onishi1, Taichi Yuasa1, Naoyuki Ueda1

  • 1Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.

Investigative ophthalmology & visual science
|August 26, 2025
PubMed
概括

由于内质网膜 (ER) 的压力,p38 MAPK是Fuchs内皮角膜缩 (FECD) 细胞死亡的关键媒介. 通过减少细胞死亡,抑制p38MAPK显示了FECD的治疗潜力.

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