氧化物与氧化物与聚乙烯糖醇作为治疗直肠形的治疗方法:随机交叉试验
Butsarin Nate-Anong1, Jiraporn Khorana1,2,3,4, Sireekarn Chantakhow1,2
1Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Pediatric surgery international
|August 26, 2025
概括
这项研究没有发现Sennosides,氧化物或聚乙烯糖醇治疗ARM患者便秘的疗效或使用者偏好有显著差异. 这三种药在便清除和患者满意度方面表现相似.
科学领域:
- 胃肠病学
- 药理学
- 临床医学
背景情况:
- 便秘是患有直肠形 (ARM) 的患者常见的问题.
- 有效治疗便秘对于改善ARM患者的生活质量至关重要.
- 松剂,氧化 (Mg(OH) 2) 和聚乙烯糖醇 (PEG) 是常用的.
研究的目的:
- 为了比较Sennosides,Mg (OH) 2和PEG在手术纠正ARM患者的便秘治疗中的疗效和使用者偏好.
- 评估处理后的便负荷和清洁便负荷的速度.
- 评估患者在三种不同的药治疗中的偏好.
主要方法:
- 一个随机交叉试验,涉及15名手术纠正的ARM和便秘的患者.
- 每个患者都接受了Sennosides,Mg (OH) 2和PEG在21天的时间内.
- 主要结果:通过李奇评分排泄便;次要结果:清洁排泄便率和用户偏好评分.
主要成果:
- 平均李奇评分是可以比较的:Sennosides (6.67±2.09),Mg ((OH) 2 (6.80±2.37),和PEG (5.80±2.04) (p=0.841).
- 清洁便负荷率为Sennosides的40%,Mg{OH}2的46.67%和PEG的60% (p=0. 655).
- 用户偏好Sennosides (7.00±2.36),而不是MgO) 2 (6.33±2.94) 和PEG (5.06±2.28) (p=0.582),第三个时期MgO) 2的偏好有所下降.
结论:
- 在ARM患者中,没有发现Sennosides,Mg (OH) 2和PEG对便秘的疗效或使用者偏好的统计学显著差异.
- PEG显示出更好的便清除趋势,而Sennosides获得了更高的用户偏好.
- 可能需要进一步的研究来探索细微的差异或特定的患者子组.
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