通过向Wnt/β-Catenin通路对抗Wistar大鼠中链杆菌诱导的糖尿病外围神经病的Eriodictyol的神经保护活性
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在PubMed上查看摘要
概括
此摘要是机器生成的。通过减少高血糖和神经损伤,缓解糖尿病外围神经病变 (DPN). 这项研究表明ED可以通过调节Wnt/β-catenin通路来缓解DPN.
科学领域
- 生物化学
- 药理学
- 神经科学
背景情况
- 长期高血糖和胰岛素功能障碍会导致周围神经损伤,导致糖尿病周围神经病变 (DPN) 的感觉丧失和疼痛.
- 在葡萄糖诱导的DPN中涉及Wnt/β-catenin通路.
- 埃里奥迪克提醇 (Ed) 显示出对葡萄糖毒性的潜在保护作用.
研究的目的
- 为了研究Eriodictyol (Ed) 的疗效,该药物应用于链杆菌诱导的DPN大鼠模型中.
- 探索Wnt/β-catenin通路在ED对DPN的生物活性中的作用.
主要方法
- 给Wistar大鼠施用STZ诱导DPN,然后用ED,加巴丁 (Gpn) 或甲基酸盐 (MV) 治疗4周.
- 评估的代谢参数 (体重,多,多,高血糖,HbA1c,HOMA- IR,胰岛素,HOMA- β).
- 评估的坐骨神经标志物 (氧化应激,炎症,晚期糖化终产物,NF-κB,Wnt/β-catenin通路) 和感觉反应 (共振,过敏).
主要成果
- 在STZ诱导的DPN大鼠中,治疗显著改善了代谢参数,包括降低了高血糖和HbA1c,提高了胰岛素水平.
- 在坐骨神经中减轻了氧化应激,炎症,高级糖化终产物和NF-κB.
- 在神经病的老鼠中,ED和Gpn治疗减少了Wnt/β-cateninmRNA的表达,改善了过敏症和形症.
结论
- 埃里奥迪克 (Ed) 有效地缓解了糖尿病外围神经病变 (DPN) 的病态进展.
- 似乎Wnt/β-catenin通路参与了ED对DPN相关疼痛的治疗作用.
相关概念视频
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...