人体身高与男性的癌症风险增加
Cecilia Radkiewicz1, Gustaf Edgren2,3, Arvid Sjölander1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
International journal of cancer
|August 26, 2025
概括
男人面临更高的癌症风险,部分原因是身材更高. 这项研究表明成年人身高解释了男性癌症风险的很大一部分, 突出了生活方式之外的生物因素.
科学领域:
- 癌症学
- 人类生物学
- 流行病学
背景情况:
- 与女性相比,男性患大多数癌症的发生率更高.
- 人身高是癌症发病率增加的已知危险因素.
- 平均而言,男性的身高高高于女性,
研究的目的:
- 调查成年人身高作为干细胞数量的代表, 如何解释男性的癌症风险增加.
- 量化男性性别与成年人身高介导的特定癌症风险之间的关系.
主要方法:
- 基于人口的队列研究,使用与国家癌症和死亡原因登记 (1960-2011) 相关的瑞典征兵,母亲和护照数据.
- 用中介生存分析来估计身高对男性性别癌症风险的影响.
- 统计学显著性是通过0. 05显著性水平的双面测试来确定的.
主要成果:
- 这项研究分析了6,156,659名成年人,确定了285,778例非性别特异性癌症.
- 在39个部位中,男性的性别与33个部位的癌症风险有显著的关联;在39个部位中,27个部位的更高的身高与更高的风险相关.
- 成年人的身高占男性癌症风险的0.5%~100%,特别是唾液腺癌,结肠癌,黑色素瘤和急性髓性白血病.
结论:
- 在男性中观察到的多余癌症风险的很大一部分可以归因于他们的成人身高.
- 这些发现强调了随机生物过程,遗传和早期身高决定性因素在癌症风险中的作用.
- 高度介导的癌症风险在具有有限的环境风险因素的恶性瘤中显得最一致,这表明内在的生物机制.
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