性别对急性多克索鲁肌功能障碍和预先训练的反应
Ryan N Montalvo1, Branden L Nguyen, Vivian Doerr
1University of Florida, Department of Applied Physiology and Kinesiology, Gainesville, FL.
Medicine and science in sports and exercise
|August 26, 2025
概括
运动预先训练可以提高耐力,但只能保护雌性大鼠免受多克索鲁比引起的心肺肌肉毒性. 这项研究强调了对化疗和运动干预的性别特异性反应.
科学领域:
- 心血管科学
- 运动生理学
- 药理学
背景情况:
- 多克索鲁比辛 (DOX) 是一种重要的化疗药物.
- 由于心肺肌肉毒性,其临床使用受到限制.
- 在DOX毒性和运动保护方面的性别差异尚未完全理解.
研究的目的:
- 研究多克索鲁比诱导肌肉毒性的性别差异.
- 确定运动预调能否减轻与DOX相关的肌肉损伤.
- 探索运动对化疗毒性的性别特异性保护作用.
主要方法:
- 成年雄性和雌性小鼠接受了久坐或运动预调.
- 小鼠接受了盐水或多克索鲁比辛 (20 mg/ kg).
- 在注射后48小时评估心脏和呼吸肌肉功能.
主要成果:
- 运动提高了男女的运动耐受性.
- 在男性和女性中, doxorubicin 降低了心脏和腹膜功能.
- 仅在雌性大鼠中进行心脏和隔膜功能预先调节的运动.
- 在荷尔蒙,DOX积累和基因表达方面观察到性别特异.
结论:
- 在两性中都会引起心肺肌肉毒性.
- 运动预先训练可以提高耐力,但只能在女性中提供心脏和腹膜保护.
- 研究结果表明,多克索鲁比辛的毒性和运动效益是基于性别的.
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