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研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
身体健康的瘤特征:临床前模型的见解

身体健康的瘤特征:临床前模型的见解

Alejandro Santos-Lozano , Abel Plaza-Florido ¹, Pedro Carrera-Bastos , Inmaculada Pérez-Prieto ², Alejandro Hernández-Belmonte ³, Fatemeh Kamalinejad ⁴, Beatriz G Gálvez , Juan A López , Jorge Lumbreras ⁵, Cecilia Rincón-Castanedo ⁶, Asunción Martín-Ruiz ⁷, Steven J Fleck ³, Alejandro López-Soto , Natalia Yanguas-Casás ⁸, Tomàs Pinós , Alejandro Lucia ³, Carmen Fiuza-Luces ⁸

Alejandro Santos-Lozano , Abel Plaza-Florido ¹, Pedro Carrera-Bastos

¹Research Center for Exercise Medicine and Sleep/Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, Irvine, CA.
²Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, DENMARK.
³Department of Sports Sciences. Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Madrid, SPAIN.
⁴Institut de Recerca Vall d'Hebron (VHIR), Barcelona, SPAIN.
⁵Proteomics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, SPAIN.
⁶Faculty of Physical Activity and Sport Sciences, Universidad Nebrija, Madrid, SPAIN.
⁷Department of Cellular Biology, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, SPAIN.
⁸Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, SPAIN.

⁰Research Center for Exercise Medicine and Sleep/Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, Irvine, CA.

Medicine and Science in Sports and Exercise +

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2025年八月26日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

心血管健康和肌肉强度与儿童高风险神经母细胞瘤的严重程度和瘤蛋白质特征有关. 这项研究确定了将身体健康与儿童癌症生物学联系起来的潜在机制.

科学领域

儿童瘤学
癌症生物学
运动生理学

背景情况

心脏呼吸能力 (CRF) 和肌肉力量与成人癌症风险和死亡率有关.
在儿童癌症,特别是高危神经母细胞瘤 (HR-NB) 中缺乏这种关联的证据.

研究的目的

在HR-NB中调查CRF,肌肉强度和与瘤相关的表型之间的关联.
确定与儿童恶性瘤相关的新型瘤蛋白质特征.

主要方法

通过跑步机和握力测试对小鼠进行CRF和肌肉强度的评估.
评估瘤结局,包括存活率,临床严重程度,体重,体积,转移和免疫透.
进行了定量蛋白质组分析并绘制了蛋白质与蛋白质相互作用 (PPI),以确定与适应性参数的相关性.

主要成果

CRF与瘤的临床严重程度相反相关 (r = - 0. 657, p = 0. 020).
鉴定出76种瘤蛋白与CRF显著相关,194种与肌肉强度相关.
与CRF相关的蛋白质与代谢和结构途径有关,而与肌肉强度相关的蛋白质则涉及结构组织和细胞粘附途径.

结论

在HR-NB中,CRF与临床严重程度的降低有关.
在HR-NB中发现了与CRF和肌肉强度相关的新型蛋白质特征.
这些发现突出了身体健康与儿童癌症发展和进展的潜在生物机制.

关键词:

癌症心脏呼吸能力运动肌肉力量瘤学瘤生物学瘤免疫透物

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相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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