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Updated: Sep 10, 2025

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
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将药物代谢物转化为双β-上腺素受体-碳酸无水酶调节剂作为治疗眼部疾病的潜在工具

Andrea Ammara1, Alessandra Carone1, Laura Lucarini2

  • 1NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy.

Journal of medicinal chemistry
|August 26, 2025
PubMed
概括

研究人员化学修改了mirabegron的代谢物,制造了双重向的碳酸无水酶抑制剂和β3上腺素受体激活剂. 化合物14在体内显著降低眼内压力,这表明可能治疗眼睛高血压.

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