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三重DNA-银纳米集群:可调节的光和光增强的抗菌活性

Yuhan He¹, Yuxuan Xue¹, Xinyao Yi¹

¹Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, P. R. China.

ACS applied bio materials

|August 26, 2025

概括

研究人员使用三链DNA (tsDNA) 开发了可调节的光银纳米集群. 这些tDNA- AgNCs表现出增强的抗菌活性,具有生物感知和改善治疗的潜力.

科学领域:

纳米技术
生物化学
材料科学

背景情况:

银纳米集群 (AgNCs) 对生物感知和抗菌用途具有前景.
三链DNA (tsDNA) 为新材料设计提供结构灵活性.

研究的目的:

构建具有可调节光和增强抗菌性能的tDNA-AgNCs.
研究光增强和抗菌活性的机制.

主要方法:

在tDNA模板上使用丰富的细胞因子序列合成AgNCs.
通过改变DNA模板中的细胞因子数来调整光发射.
评估对大肠杆菌和金色葡萄球菌的抗菌活性.
评估蓝光照射对tsDNA-AgNCs抗菌能力的影响.

主要成果:

与传统的AgNC相比,tDNA- AgNC的光显著增强.
通过修改DNA模板, 光色可以从红色调整为绿色.
这种DNA- AgNCs对格拉姆阴性和格拉姆阳性细菌具有强烈的抗菌活性.
通过增加反应性氧物种 (ROS) 和银离子 (Ag+) 释放,蓝光照射增强了抗菌作用.

结论:

稳定DNA的AgNC代表了先进生物传感应用的多功能平台.
开发的tsDNA-AgNCs为增强抗菌治疗提供了一个有前途的策略.

关键词:

DNA-AgNCs 的使用富G的序列增强光的抗菌活性三重DNA 可调节的光

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