自我和告密者报告的记忆障碍和轻度认知障碍向痴呆症的进展之间的不一致
Patrícia Regueira1,2, Inês Baldeiras1,2, Marisa Lima2,3
1Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Aging & mental health
|August 26, 2025
概括
患有轻度认知障碍的患者报告的记忆丧失显示意识受损,并且患痴呆症的风险显著增加. 这种报告不足与阿尔茨海默病的生物标志物有关.
科学领域:
- 神经学
- 老年学
- 神经科学
背景情况:
- 轻度认知障碍 (MCI) 是正常衰老和痴呆之间的过渡阶段.
- 评估对记忆缺陷的认识对于了解MCI疾病进展至关重要.
- 患者和告知者报告之间的差异可能表明自我意识受损.
研究的目的:
- 评估患者报告中记忆缺陷的差异是否代表MCI的意识受损.
- 确定这种差异在预测转化为痴呆症的预后价值.
主要方法:
- 对128名患有MCI记忆障碍的患者进行了长度研究.
- 基线评估包括阿尔茨海默病 (AD) 生物标志物,主观记忆问题 (SMC) 和认知功能 (MMSE).
- 参与者被跟踪平均43. 3个月,以追踪转化为痴呆症.
主要成果:
- 记忆障碍报告不足的人的认知表现较低,报告SMC的信息者较高.
- 报告者表现出更大的粉样蛋白,蛋白和p-tau负担.
- 报告不足与痴呆症转变的风险增加了4. 31倍.
结论:
- 患者报告不足的记忆缺陷独立预测了MCI的疾病进展.
- 报告与阿尔茨海默病生物标志物相关,支持报告不足作为意识受损的标志物.
- 记忆缺陷的低报告是MCI患者痴呆转化的重要预测因素.
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