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Updated: Sep 10, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

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皮奥切林生物合成的填充性表皮酶域是已不存在的甲基转移酶

Trey A Ronnebaum1, Kathleen M Meneely2, Geoff P Horsman3

  • 1Department of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.

Biochemistry
|August 26, 2025
PubMed
概括

非核糖体合成酶 (NRPS) 通常使用表皮酶域进行D-氨基酸结合. 然而,2-基亚天然产品中的"填充"表皮酶域似乎具有催化不活性,这表明它们是非功能性甲基转移酶.

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