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Updated: Jun 20, 2026

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
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单细胞空间转录学揭示了腹动脉动脉瘤的细胞格局

Guizhen Zhao1,2, Chun-Seok Cho3, Hongyu Liu1

  • 1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

JCI insight
|August 26, 2025
PubMed
概括

空间转录学显示高GPNMB的巨细胞通过诱导光滑肌肉细胞功能障碍驱动腹腔大动脉瘤 (AAA) 的进展. 这一发现为这种危及生命的血管疾病提供了新的治疗点.

关键词:
心脏病学心血管疾病血管生物学

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相关概念视频

Overview of Cell-Matrix Interactions01:24

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...