整合光学和参数共振微扫描器设计,用于大工作距离的植入式显微镜
Tayebeh Sahraeibelverdi1, Ahmad Shirazi2, Miki Lee3
1Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 USA.
IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division
|August 26, 2025
概括
本研究为微型植入式光显微镜提供了优化的设计,集成光学路径和微电机械系统 (MEMS) 扫描镜. 这种新的方法提高了神经科学研究中的扫描率.
科学领域:
- 生物医学工程
- 光学工程
- 微电机系统
背景情况:
- 开发微型植入式光显微镜对于体内生物研究至关重要.
- 在保持亚细胞分辨率的同时,实现大工作距离 (WD) 和视野 (FOV) 提出了重大设计挑战.
研究的目的:
- 研究微型植入式光显微镜的光学路径和微电机械系统 (MEMS) 扫描镜的相互依赖设计.
- 用特定的WD和FOV来最大化高NA聚焦的扫描速率,从而实现高效的地下成像.
主要方法:
- 使用线性和数值射线分析来解光学和机械设计方面.
- 组合动态旋转分析与参数共振静电MEMS扫描镜的新型故障电压模型.
- 优化镜像参数以适应光学限制,并选择适合小目标直径的光学路径.
主要成果:
- 开发了一种能够进行细胞下分辨率成像的原型仪器.
- 在工作距离 (WD) 最多为300μm时,达到大约500×500μm的视野 (FOV).
- 验证了原型对成像目标和切除小鼠大脑组织的性能.
结论:
- 相互依赖的设计方法成功地集成了光学和MEMS扫描镜组件.
- 开发的微型显微镜为先进的体内成像应用提供了显著的潜力,特别是在神经科学领域.
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