用于模块化水凝交叉连接的聚乙烯基醇-胺-诺伯烯-碳酸盐的水性合成
Nathan H Dimmitt1, Chien-Chi Lin1
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Advanced materials interfaces
|August 26, 2025
概括
我们开发了一种完全水性合成PEG-amide-norbornene-carboxylate (PEGaNBCA) 水凝. 这些稳定,可调节的水凝非常适合生物医学应用,包括干细胞维护和数字光处理打印.
科学领域:
- 生物材料科学
- 聚合物化学
- 水凝工程
背景情况:
- 聚乙烯基醇 - 诺伯 (PEGNB) 是一种用于水凝应用的多功能宏聚物.
- 目前的PEGNB合成方法严重依赖有机溶剂,造成环境和健康风险.
- 需要更环保,更高效的PEGNB基材料合成途径.
研究的目的:
- 开发一种全水合成的新型PEGNB大分子,PEG-amide-norbornene-carboxylate (PEGaNBCA).
- 为了研究PEGaNBCA水凝的交联能力和特性,使用醇-诺波光聚合和反向电子需求迪尔斯-阿尔德 (iEDDA) 点击化学.
- 评估基于PEGaNBCA的水凝的水解稳定性和降解概况以及它们的可调性降解潜力.
主要方法:
- 通过与氨基终端 PEG 反应碳酸 (CA) 来完全水性合成 PEGaNBCA.
- 使用硫醇 - 诺伯光聚合和四 - 诺伯iEDDA点击反应对PEGaNBCA进行交叉连接.
- 评估水凝的水解稳定性,通过混合,数字光处理 (DLP) 打印和*in situ*细胞封装进行调节的降解.
主要成果:
- 通过环保的全水路成功合成PEGaNBCA.
- PEGaNBCA水凝通过醇- 诺伯和iEDDA反应表现出强大的交叉连接.
- 与含的同类药物相比,PEGaNBCA水溶具有更高的长期水解稳定性.
- 通过将PEGaNBCA与水溶性不稳定的PEGeNBCA混合来实现调节性降解.
- 已经证明了高准确度的DLP打印和成功的实地封装和维持人类诱导多能干细胞 (hiPSCs).
结论:
- PEGaNBCA为传统的PEGNB巨分子提供了一个可持续和多功能替代品.
- 开发的水凝具有可调节的特性,包括水解稳定性和降解性,用于先进的生物医学应用.
- PEGaNBCA水凝适用于3D打印并保持干细胞活力,突出显示了它们的转化潜力.
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