对有限阶段小细胞食道癌的外科治疗:回顾性队列研究
Jun Peng1, Jin-Feng Chen2, Yi Wang3
1Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
在有限期小细胞食道癌 (LS- SCEC) 中,外科治疗显著改善了存活率. 新辅助化疗可提高整体存活率,大多数LS- SCEC患者应接受辅助化疗.
科学领域:
- 癌症学
- 外科瘤学
- 胃肠道瘤学
背景情况:
- 限期小细胞食道癌 (LS-SCEC) 的最佳治疗方法尚未确定.
- 这项研究以后评估了LS- SCEC患者的外科治疗疗效.
研究的目的:
- 评估术后治疗对LS-SCEC生存结果的影响.
- 确定接受食道切除的LS-SCEC患者的独立预后因素.
主要方法:
- 对156名经过食道切除的LS- SCEC患者的回顾性分析 (2005年6月 - 2022年11月).
- 主要终点:整体存活率 (OS). 二级终点:无病生存率 (DFS) 和术后并发症.
- 倾向分数匹配 (PSM) 和考克斯回归模型分析了预后因素.
主要成果:
- 新辅助化疗显著改善了生存率 (5 年生存率: 37. 7% 对比 0. 0%; P < 0. 001).
- 辅助疗法 (化疗或放射性化疗) 与改善的生存状况和DFS有关.
- 临床T阶段,神经侵袭,N阶段和辅助疗法是独立的预后因素.
结论:
- 术后治疗对于管理LS-SCEC至关重要.
- 新辅助化疗对LS- SCEC患者的生存有显著的益处.
- 强烈建议几乎所有LS- SCEC患者在手术后接受辅助化疗.
更多相关视频
09:04Low-Cost Single-Port LoCoSP Device for a Transcervical Approach in Minimally Invasive Transhiatal Esophagectomy
Published on: September 11, 2021
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
相关概念视频
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
