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用于声动力化学治疗的可调节带隙的Ce调节的氧固体溶液的性能

Yanan Guo¹, Jiaxu Wei¹, Guoying Tan¹

¹State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China.

ACS applied materials & interfaces

|August 26, 2025

概括

这项研究引入了Ce-Ti-O固体溶液,用于增强声动疗 (SDT) 和化学动疗 (CDT) 治疗乳腺癌. 这种新材料改善了反应性氧物种的产生和瘤抑制.

科学领域:

生物医学工程
材料科学
癌症学

背景情况:

使用半导体纳米材料的声动疗法 (SDT) 对癌症治疗具有前景.
由于电子孔快速重组,电流敏感器的宽带间隔限制了SDT的有效性.
开发具有优化带结构的新材料对于改进SDT至关重要.

研究的目的:

设计具有可调节带隙的Ce-Ti-O固体溶液 (CTO),用于增强超声触发SDT.
用CTO研究SDT和化学动态治疗 (CDT) 的联合疗效,用于治疗耐火性乳腺癌.
建立精确瘤治疗的新纳米平台,并探索固体解决方案的多功能应用.

主要方法:

制造具有不同剂度的Ce-Ti-O固体溶液 (CTO) 纳米材料.
在超声波照射下评估载体分离效率和带隙结构修改.
对H2O2转化为基 (·OH) 的芬顿类反应性进行评估.
评估细胞毒性,活性氧物种 (ROS) 生成,线粒体损伤和对乳腺癌的瘤抑制作用的体外和体内研究.

主要成果:

在超声波下显著提高载体分离效率.
CTO表现出类似芬顿的活性,从内源的H2O2中产生OH用于CDT.
结合SDT和CDT的方法导致癌细胞中的ROS产生和线粒体损伤增加.
在实验室和体内对耐药乳腺癌模型观察到显著的细胞毒性和瘤抑制.

结论:

Ce-Ti-O固体解决方案是结合SDT和CDT的有效平台,克服了传统SDT的局限性.
这种方法显著增强了ROS生成,并对耐火性乳腺癌表现出强烈的抗瘤作用.
这项研究为生物医学中的多功能固体溶液材料提供了一个新的纳米诊断平台和理论基础.

关键词:

化学动力学治疗反应性氧物种固体溶液声动力学疗法有毒性

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