牙衰老的遗传环境风险因素:中国的一项家庭病例对照研究
Xinyue Guo1, Taoyun Xu1, Xiaohong Duan1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, Clinic of Oral Rare and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, PR China.
International dental journal
|August 26, 2025
概括
牙发育 (TA) 是高度可遗传的,特别是在女性身上,遗传因素起着重要作用. 环境因素,如电磁辐射, 也有助于TA的发展.
科学领域:
- 牙科遗传学
- 发育生物学
背景情况:
- 牙发育 (TA) 是一种普遍的牙异常,在大量人群中遗传和环境影响不明.
- 了解这些因素对于诊断和治疗TA至关重要.
研究的目的:
- 调查中国人口对牙发育 (TA) 的遗传和环境贡献.
- 分析与TA相关的遗传性和遗传模式.
主要方法:
- 一个基于家庭的病例对照研究,涉及106个TA家庭和197个对照.
- 临床检查,风险因素评估,遗传性估计和遗传分析 (整个外体和桑格测序).
主要成果:
- 估计TA的遗传率为82.1%,女性更高. 随着环境暴露的增加,遗传贡献也在减少.
- 确定了单基因,寡基因和其他遗传模式. 关键基因包括WNT10A,EDA和PAX9.
- 家庭病史增加了TA风险的20倍;在怀孕期间不受保护的电磁辐射暴露增加了风险的4倍.
结论:
- 遗传因素在TA中很重要,特别是在严重的病例和女性中,随着环境暴露而降低遗传性.
- 在TA家族中存在多种遗传模式.
- 环境因素,如电磁辐射,可能有助于TA的发展.
相关概念视频
Teeth
676
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
676
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Human Genetics
719
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
719
Incomplete Dominance
25.4K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
25.4K
Lethal Alleles
15.7K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.7K
Genomic Imprinting and Inheritance
35.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.2K


