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选择性识别S-rivastigmine的碳化聚合物的化学驱动后印记

Munirah S O Alhar¹, Odeh A O Alshammari¹, Ahmed Al-Otaibi¹

¹Department of Chemistry, College of Science, University of Ha'il, Ha'il 81451, Saudi Arabia.

Journal of chromatography. A

|August 26, 2025

概括

一种新的分子印记聚合物 (MIP),S-RV-P,已开发用于选择性S-rivastigmine (S-RV) 分离. 这种聚合物具有很高的亲和力和反选择性,显示出有效的药物净化潜力.

科学领域:

聚合物化学
基质分离科学
药物分析

背景情况:

利瓦斯蒂格是治疗阿尔茨海默症和帕金森症的重要药物.
对于治疗效果和安全性而言,瑞瓦斯蒂格的酶体纯度至关重要.
现有的分离方法可能是低效或昂贵的.

研究的目的:

开发一种新的分子印记聚合物 (MIP),用于选择性地识别和分离瑞瓦斯蒂格的S-反体 (S-RV).
研究S-RV-P聚合物的合成,表征和性能.
评估S-RV-P在药物抗纯度应用中的潜力.

主要方法:

用醇和碳酸组功能化的聚乙烯-基无水合物基质的合成.
使用S-RV促进的thiol-maleimide点击交叉连接进行后印记.
聚合物的动力,热力学和热分析.
吸附实验,同热模型 (Langmuir) 和选择性评估.
引力柱分离以进行奇拉分辨.

主要成果:

该S-RV-P聚合物对S-RV具有很高的亲和力,大约是非印记聚合物 (NIP) 的两倍.
在pH值为6-7,最大容量为326 mg/ g时,依据Langmuir异热动力学进行了最佳吸附.
实现了显著的反选择性,重力柱分离给出了R-RV的91%,S-RV的97%.
这种交联聚合物表现出更好的结构稳定性.

结论:

印制过程成功地产生了具有S-RV特定识别能力的聚合物.
S-RV-P具有显著的高分辨率奇拉分离和净化的潜力.
这种新型的MIP为药物开发和制造提供了有前途的方法.

关键词:

基质分离分子印记利瓦斯蒂格

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