重金属暴露与精液质量的地理关联:全国多中心研究
Zhipeng Zhu1, Xiaoqing Ni2, Yong Zhu3
1Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China; Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei 230032, China.
Ecotoxicology and environmental safety
|August 26, 2025
概括
地理地带的暴露对人类的精液质量有很大的影响. 混合重金属暴露加剧了这些不良影响,凸显了对生殖健康的环境健康问题.
科学领域:
- 环境健康
- 生殖毒理学
- 地理空间分析
背景情况:
- 评估重金属混合物对人类精液质量的影响是复杂的.
- 对重金属的地理暴露对环境健康构成重大挑战.
- 量化单个和联合重金属暴露对精液参数的影响至关重要.
研究的目的:
- 量化个人和联合地理重金属暴露对人类精液质量的影响.
- 通过地理空间分析识别影响精液参数的重金属.
- 研究重金属对男性生殖健康的影响.
主要方法:
- 在中国的十个精子银行招募了32 072名男性 (2019-2022年).
- 使用逆距离权重和地质探测器 (GD) 量化地理重金属暴露.
- 使用GD和通用线性混合模型 (GLMM) 评估六种土壤重金属对精液体积,精子度,运动率和总数的影响.
主要成果:
- (Hg) 是降低精子度和总精子数量的主要因素 (PD值高达0.112).
- 混合接触重金属,特别是和 (As),增加了对精液质量的负面影响.
- 地理Hg暴露与非最佳精子总数 (P < 0. 05) 有显著的积极关联,在中高暴露组中精子度降低的几率比率增加.
结论:
- 地理上的暴露被认为是精液质量下降的主要原因.
- 混合重金属暴露会对男性生殖健康产生不利影响.
- 地质探测器分析提供了对影响精液质量的环境因素的新见解.
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