工业多污染土壤中的抗生素,ARG和病原体的垂直迁移:对环境和公共健康的影响
Yinping Miao1, Xinran Liu1, Min Liu1
1Key Laboratory of Geographic Information Science (Ministry of Education), School of Geographic Sciences, East China Normal University, Shanghai 200241, China.
Ecotoxicology and environmental safety
|August 26, 2025
概括
城市土壤含有抗生素耐药性基因 (ARG) 和病原体, 污染物和土壤特性推动了ARG的传播,增加了地下水污染的风险,并需要减轻共污染物.
科学领域:
- 环境科学
- 微生物学
- 土壤科学
背景情况:
- 城市土壤是抗生素耐药性基因 (ARG) 和病原体的重要储存库.
- 工业土壤中的ARG和病原体的垂直迁移是不太了解的.
- 城市土壤中的污染物可能会影响抗生素耐药性的传播.
研究的目的:
- 在工业土壤中调查抗生素,ARG和病原宿主的垂直分布.
- 了解推动ARG传播的因素以及土壤深度的病原体丰富性.
- 评估城市工业区地下水受到ARG和病原体污染的风险
主要方法:
- 分析了上海陶普工业园区的土壤样本 (0-310厘米).
- 使用超高性能液体染色体质谱 (UPLC-MS/MS) 来量化抗生素.
- 使用元基因组测序来识别ARG和细菌群体,包括致病宿主.
主要成果:
- 抗生素度随着深度的增加而呈指数级下降,受多环芳 (PAH) 的影响.
- 在1183种ARG亚型中,有437种在深度范围内存在,其丰度随着土壤深度的增加而增加,这是由于微生物群落的转移和代谢途径.
- 粘土含量和素是细菌群落的关键驱动因素,而抗生素和粘土影响了特定的病原体丰度 (Acinetobacter和Pseudomonas).
- 在较深的土壤层 (20-310厘米) 中发现了七种致病性物种,表明潜在的地下水污染风险.
结论:
- 污染物和微生物代谢之间的协同作用促进抗生素耐药性的扩散到更深层的土壤.
- 这些发现突显出迫切需要共同污染物缓解策略来保护城市土壤系统并防止ARG的进一步传播.
- 由于ARG和病原细菌的垂直迁移,城市工业土壤存在严重的地下水污染风险.
相关概念视频
Bioremediation
20.0K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
20.0K
Development of Antibiotic Resistance
197
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
197
Environmental Applications of Microorganisms
233
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
233
Antibiotic Selection
55.2K
Overview
55.2K
Microorganisms in Medicine and Therapeutics
314
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
314
Types of Toxins
2.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.0K


