血清索提林作为尿素患者心血管化的潜在诊断和治疗点:单中心前性和观察性研究
Yuxia Zhang1, Jingjing Chen2, Yan Di2
1School of Medicine, Southeast University, Nanjing, China; Department of Nephrology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University School of Medicine, Nanjing, China.
概括
在患有慢性病的患者中,血清索提林水平升高与血管化 (VC) 和心脏形化 (CVC) 有关. 在这些高危人群中,较高的sortilin水平可能预测心血管事件.
科学领域:
- 肝脏病学
- 心脏病学
- 生物化学
背景情况:
- 心血管疾病是慢性病患者的主要死亡原因.
- 血管化 (VC) 和心脏膜化 (CVC) 是尿素患者心血管疾病的主要原因.
研究的目的:
- 在尿素患者中研究血清sortilin水平与VC和CVC之间的关联.
- 评估索提林作为慢性病中心血管并发症的潜在生物标志物.
主要方法:
- 包括212名尿素患者的横截面研究.
- 测量血清索提林水平和腹腔大动脉化得分 (AACS).
- 进行了心电回声学评估;进行了相关性,回归和ROC曲线分析.
主要成果:
- 与对照组相比,VC和CVC患者的血清分类水平显著升高.
- 血清索提林水平与AACS相关,是VC和CVC的独立风险因素.
- 索尔提林对AAC和CVC具有预测价值,而高水平与MACCE风险增加有关.
结论:
- 在尿素患者中,血清索提林升高是血管和心脏结的潜在预测因素.
- 索尔提林可能在慢性病中促进化过程.
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