双极性疾病中与自杀企图相关的DNA甲基化模式和表观遗传衰老
Marina Mitjans1, Miriam Acosta-Díez2, Anna Giménez-Palomo3
1Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.
Journal of affective disorders
|August 26, 2025
概括
像DNA甲基化和表观遗传衰老等表观遗传标记可能表明双极性障碍中自杀企图的风险. 需要进一步的研究来确定有风险的个体.
科学领域:
- 神经科学
- 遗传学
- 精神病学
背景情况:
- 自杀想法和行为 (STB) 是双极性障碍 (BD) 的重要公共健康问题.
- 表观遗传学,特别是DNA甲基化 (DNAm) 和表观遗传衰老 (EA) 是与BD中性病相关的新兴因素.
研究的目的:
- 鉴定双相情感障碍中自杀尝试的表观遗传风险因素.
- 为了比较具有和没有SA史的BD患者之间的DNA甲基化模式和表观遗传衰老.
主要方法:
- 从有 (BD/ SA) 和没有 (BD/ non- SA) 病史的BD患者的血液样本中分析了全基因组的DNA甲基化模式.
- 鉴定了差异甲基化位置 (DMP) 和区域 (DMR),并进行了基因网络分析.
- 使用已确定的表观遗传时钟来估计表观遗传衰老.
主要成果:
- 在BD/ SA和BD/ 非SA组中发现了18个DMP和2个DMR.
- MAD1L1基因被映射到DMPs/DMRs中,与严重的SA有先前的关联.
- 在使用GrimAge和GrimAge2时钟的BD/SA组中观察到年龄加速的趋势.
结论:
- 在研究精神疾病中的SA时,包括DNAm和EA在内的表观遗传标记是重要的.
- 这些发现可能有助于更好地理解BD中SA的生物学基础.
- 鉴定表观遗传标记可能有助于确定患上SA风险较高的人.
更多相关视频
相关概念视频
Epigenetic Regulation
31.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.4K
Bipolar Disorder
142
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
142
Human Genetics
719
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
719


